All tagged Genetics

Hereditary Diseases: How Do They Work?

Hereditary Diseases: How Do They Work?

Siddharth I Sharma
Science & Nature

In 1819, Queen Victoria was born with what scientists currently believe was a spontaneous mutation in her genome. Though unaffected herself, some of her children and then her grandchildren began to show signs of a bleeding disease. Her great-grandson, Alexei Romanov, would go on to seek the consultation of Grigori Rasputin to treat this condition. In time, the “royal disease” would go on to become one of the most famous examples of a hereditary disease, known more commonly today as hemophilia. However, it wasn’t until 1902 when Archibald Garrod’s observations of alkaptoneuria, highlighted the relevance of Mendel’s principles in the study of hereditary diseases (Urban, 1999). With today’s advancements in medicine, the focus naturally turns to conditions that are inherited, and whether or not a cure could ever be possible.

Gene Editing: What You Need to Know 

Gene Editing: What You Need to Know 

Siddharth I Sharma
Science & Nature

Beginning in the 19th century, the field of genetics saw significant growth in thought. Though concepts of heredity were postulated long before the term entered the scientific lexicon, it wasn’t until Gregor Mendel’s work on pea plants in 1865 that the concept of heredity was fully understood. By 1944, Avery, MacLeod, and McCarty discovered that DNA was the “transforming principle,” the fundamental chemical component of genes (“1944: DNA Is \"Transforming Principle\,"” n.d.).