Over the past few decades, extensive research has analysed the personality construct of alexithymia, due to its strong connections with a multitude of physical and psychological disorders (Luminet et al., 2004). However, the association between alexithymia and the cold-blooded personality has rarely been investigated due to its underrated importance in the medical field. The present article is the first to gather and explain the main neurological, psychosomatic, and physical links between alexithymia and the cold-blooded personality, intending to propose a novel, possible path toward the understanding of highly common physical and psychological disorders associated with both alexithymia and the cold-blooded personality.