CIPA stands for Congenital Insensitivity to Pain with Anhidrosis. As the name implies, CIPA disease is the inability to feel physical pain. It is a rare congenital and genetic disease that affects the nervous system. It is an extremely rare disorder which may also cause a person to produce very little sweat, or none at all, and makes them incapable of feeling temperature. These symptoms appear early in childhood, typically at birth or during infancy.